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The relationship between renal P-glycoprotein expression and response to steroid therapy in childhood nephrotic syndrome . (Turkmen, Mehmet.)
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The relationship between renal P-glycoprotein expression and response to steroid therapy in childhood nephrotic syndrome .
Author:
 Turkmen, Mehmet. Search Author in Amazon Books

Publisher:
Turkısh J Pedıatrıcs,
Edition:
 2013.
Classification:
 WS 18.2
Detailed notes
    - In this study, we aimed to investigate the relationship between renal P-glycoprotein (rP-gp) expression and response to corticosteroid therapy in childhood nephrotic syndrome (NS). Expression of rP-gp was evaluated prior to non-steroid immunosuppressive therapy in children with NS (Group 1), prior to any treatment in children with immunoglobulin (Ig) A nephropathy (Group 2), and during renal donation in healthy adults (Group 3); mesangial proliferation was evaluated in Groups 1 and 2. Total dosage of steroid was calculated in Group 1. The ratio of rP-gp (+) glomeruli was higher in Group 1 than Group 3 (33.8 +/- 27.1% vs 4.7 +/- 4.6%, p= 0.000). There were no rP-gp (+) glomeruli in Group 2. The rate of mesangial proliferation was similar in Groups 1 and 2. There was no statistically significant correlation between rP-gp expression and total steroid dosage (r = 0.455, p = 0.160). Our findings showed that rP-gp expression is increased in patients receiving steroid therapy for NS regardless of the cumulative steroid dosage and mesangial cell proliferation.
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Section
EOL-1456
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NEU Grand LibraryOnline (WS 18.2 .R45 2013)
Online electronic
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