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Alpha-Tocopherol and ascorbic acid in early postoperative period of cardiopulmonary bypass (Gunes, Tevfik.)

Bibliographical information (record 264571)

Alpha-Tocopherol and ascorbic acid in early postoperative period of cardiopulmonary bypass
Author:	Gunes, Tevfik. Search Author in Amazon Books

Edition:	2012.
Classification:	WG100
URL:	http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.2459/JCM.0b013e328356a2dc

Detailed notes

- Aim To investigate whether alpha-tocopherol and ascorbic acid have effect on the suppression of inflammation in the early postoperative period after open heart surgery. Methods A total of 59 patients who had undergone cardiopulmonary bypass (CPB) in the Cardiovascular Surgery Department of a tertiary center between June 2008 and December 2008 were retrospectively investigated. The study group consisted of 34 patients (25 men, 9 women) to whom ascorbic acid (500 mg/day) and alpha-tocopherol (300 mg/day) were administered on the day of operation (0th day) and the first four consecutive postoperative days. In contrast, 25 controls (20 men, 5 women) received no additional anti-inflammatory medications. The two groups were compared in terms of demographics, blood parameters such as C-reactive protein (CRP) and white blood cell (WBC) count, and durations of cross-clamp and CPB. Results In the control group, CRP levels were found to be increased on the first postoperative day (P < 0.001) and CRP levels were correlated with triglyceride levels on the day of operation (P = 0.009) and the first postoperative day (P = 0.021). On the second postoperative day WBC count was found to be decreased (P = 0.008) and correlated with glucose level (P < 0.005). In the study group, CRP levels were found to be inversely correlated with serum high-density lipoprotein (HDL) (P = 0.049) on the first postoperative day and directly correlated with triglyceride levels on the second postoperative day (P = 0.017). Blood glucose levels were found to be increased on the first postoperative day (P = 0.021) and a correlation was detected between WBC count on the fourth postoperative day and doses of ascorbic acid ad alpha-tocopherol (P = 0.027). Conclusion Suppression of the systemic inflammatory response to CPB is a double-edged sword and whether this suppression aids in the attenuation of morbidity and mortality is obscure. In this respect, ascorbic acid and alpha-tocopherol seem to display some antiinflammatory effect, but further studies are necessary to reveal the actual therapeutic potential and the complex mechanism related to biochemical and inflammatory parameters. J Cardiovasc Med 2012, 13:691-699